Bundles of axons in porcine brain: 3,500x magnification using scanning electron microscopy [Rashid, Destrade and Gilchrist (Galway/Dublin)]

Nanostructured, biocompatible scaffold to support 3D cell cultures with controled mechanical properties [Sonia Contera (Oxford)]

MEG data visualization and navigation tool: Synchronization biomarkers of MCI patients [Antonio Gracia (UPM)]

High-detailed synapse reconstruction: Electronic microscopy image segmentation by ESPINA software and rendered by GMRV [Marcos Garcia / Angel Rodriguez (URJC/UPM, Cajal Blue Brain)]

Numerical model of a neuron under mechanical loading [Antoine Jerusalem (Oxford)]

UPM's 3D virtual reality cave facility: Mini-column reconstruction from microscopy real-time rendered with RTNeuron [Juan Hernando (UPM, Blue Brain Project)]

Neurites from SH-SY5Y neurons penetrate through an Isopore membrane [Hua Ye (Oxford)]

In silico indentation of the brain [Pablo Saez (Oxford)]

The International Brain Mechanics and Trauma Lab (IBMTL)

The lab is an international initiative that was created in 2013. It involves the collaboration 37 academics and clinicians, across 20 main institutions.

All members of the IBMTL are heavily involved in collaborative projects related directly to brain mechanics and trauma. The interaction between experts, from such a wide range of disciplines, is motivated by the need for multidisciplinary expertise to study the relationship between brain cell/tissue mechanics and brain functions/diseases/trauma:

  • Biology: stem cells, tissue engineering, physiopathology
  • Computing: supercomputing, neuroinformatics, image processing, big data analytics
  • Engineering: materials engineering, biomechanics, computational mechanics of materials, mechanobiology, systems engineering
  • Mathematics: mathematical modelling, computational statistics, continuum mechanics, data mining
  • Medical/Clinical: neurology, neuropathology, neuroimaging, veterinary medicine, neurosurgery, psychiatry
  • Neuroscience: translational neuroscience, functional connectivity and brain network architecture, brain plasticity computational modelling
  • Physics: nanoscience, cells/tissues nanomechanics, cell rheology, shockwave/ultrasound physics, biophysics

The collaboration is centred around the complementary collaboration of experts, from different disciplines, focussed on the study of the brain cell and tissue mechanics, and its relation with brain functions, diseases or trauma.

News

IBMTL NEWS

New Review: "Mechanotransduction in cell development and functioning" by Carsten Schulte, published in Biophysical Reviews

17 Oct 2019

The review gives an overview about the role mechanotransductive mechanisms play in neuronal cell development and functioning, with a particular focus on what happens during mechanosensing of biophysical cues in the cell/microenvironment interface. Furthermore, biomaterial and biophysical approaches are highlighted that are used to study and control these processes.

Website Relaunch

07 Aug 2019

Welcome to our new website, redesigned with IBMTL members in mind. You now have a tool to promote your research, inform people about events, and share opportunities for collaboration. Share your news and images, just email us, and they will appear here if by magic.

Computing’s Key to Vital Gains in Brain Research

27 Feb 2018

SES members the University of Oxford and University College London (UCL) are making a major contribution to this breakthrough era in brain research.

Brain disease affects 99% of NFL players

25 Jul 2017

New study in Journal of the American Medical Association shows “Brain disease affects 99% of NFL players”. Authors include Dr. Ann McKee and IBMTL member Prof. Lee Goldstein from Boston University.

Events

IBMTL EVENTS

"Brain Computational Mechanics" mini-symposium at the joint 14th World Congress in Computational Mechanics and ECCOMAS Congress 2020, 19-24 July 2020, Paris, France.

15 Oct 2019

The multiphysics of the brain has been the subject of a growing body of research in the recent years. In particular, the view that the brain is a physical entity subject to mechanical laws has allowed for the consideration of brain functions, traumas and diseases as phenomena directly related to morphology, brain and cell mechanics. The answer to many of these problems require invariably close collaborations between scientists in different disciplines including clinicians, biologists, engineers and mathematicians. Due to the complexity of experimental validations, it is also naturally dependent on numerical modelling. In silico testing is however not exempt of its own complexities: patient specific geometries, subsequent meshing, multiphysics constitutive modelling, multiscale approaches, among others, are all potential pitfalls experienced by the current research programmes. This symposium will focus on various aspects of brain computational mechanics. It will address new fundamental challenges of brain computational mechanics including both the classical point of view of biomechanics (e.g., constitutive modelling and mathematical implementations), as well as the numerical aspects of the different implementations (e.g., scheme convergence, multiphysics aspects) and aims at gathering experts of all fields.

“S10: Mechanics of biological materials & biomechanics” mini-symposium at the 17th European Mechanics of Materials Conferences (EMMC), Madrid, Spain 27-29 May 2020

15 Oct 2019

Mechanics plays a prominent role in the study of biological systems and processes. In particular, it is increasingly clear that the vast majority of physiological and pathological processes encountered in micro-heterogeneous biological materials are based on phenomena driven by different concurrent physics such as mechanics, biochemistry, electricity (or electrophysiology) and thermodynamics. Physiological and pathological processes span multiple scales in length, time and energy and, even then, one process’ scales can sit at one end or another depending on whether it is considered in isolation or along with its larger systemic interaction to generate function at a higher level. Although, to some extent, traditional applied material mechanics concepts are a priori directly applicable to describe biological materials, their inherent property to adapt to mechanical and chemical environments remains a challenging modeling task and requires dedicated multiscale and multiphysics frameworks. In modelling tissue mechanics and mechanobiology, advanced material mechanical models thus need to become multiphysics models. The main goal of this session is to attract scientists from a wide variety of disciplines interested in such multiphysics considerations in the context of biology. This symposium should be a good opportunity for the participants to refine their ideas for future work and to establish possible cooperation.

Symposium on Focused Ultrasound Neuromodulation, 23-24 Sept, Oxford

30 May 2019

Focused ultrasound is rapidly becoming the next generation brain stimulation: non-invasive, focal, deep brain neuromodulation. Pioneers and leaders in the field will speak at a 2-day international symposium on 23-24 Sept, 2019, at Oriel College, Oxford. This event will bring together researchers developing and using ultrasound as a tool for stimulation and manipulation of the brain and take an integrative and translational approach.

5th OXFORD INTERNATIONAL WORKSHOP ON NEURON AND BRAIN MECHANICS

01 Jan 2018

5th OXFORD INTERNATIONAL WORKSHOP ON NEURON AND BRAIN MECHANICS - Thursday 22 and Friday 23 March, 2018. St Hugh’s College, Oxford.